UCLA psychologists have discovered a circuit in the brain of mice that makes them crave food and seek it out, even when they are not hungry. What is interesting about this discovery is that when the group of cells is stimulated, the mice seek fatty and pleasurable foods such as chocolate instead of healthier foods such as carrots.

The area of the brain where the cells are located is called the periaqueductal gray which is in the brainstem. When these cells are stimulated, the mice are so driven to eat that they will endure foot shocks to get to the food. The opposite occurs when the researchers inject a virus that produces a protein that reduces the cells activity even hungry mice foraged less.

“Like mice, humans also possess vgat PAG cells in the brainstem. It could be that if this circuit is overactive in a person, they might feel more rewarded by eating or crave food when not hungry. Conversely, if this circuit is not active enough, they could have less pleasure associated with eating, potentially contributing to anorexia. If found in humans, the food-seeking circuit could become the treatment target for some kinds of eating disorders.”

Sue’s Note: If mice have this cluster of cells, it stands to reason that other animals have it as well. Could this be why some of our pets overeat and some have low appetites?

Journal Reference:

1. Fernando M. C. V. Reis, Sandra Maesta-Pereira, Matthias Ollivier, Peter J. Schuette, Ekayana Sethi, Blake A. Miranda, Emily Iniguez, Meghmik Chakerian, Eric Vaughn, Megha Sehgal, Darren C. T. Nguyen, Faith T. H. Yuan, Anita Torossian, Juliane M. Ikebara, Alexandre H. Kihara, Alcino J. Silva, Jonathan C. Kao, Baljit S. Khakh, Avishek Adhikari. Control of feeding by a bottom-up midbrain-subthalamic pathway. Nature Communications, 2024; 15 (1) DOI: 10.1038/s41467-024-46430-5

Cite This Page:

University of California – Los Angeles. “Craving snacks after a meal? It might be food-seeking neurons, not an overactive appetite.” ScienceDaily. ScienceDaily, 20 March 2024. <www.sciencedaily.com/releases/2024/03/240320122517.htm>.