Some dogs have adverse reactions to the drugs used in anesthetics. This is due to a rare genetic mutation that originally was associated with Greyhounds, but further research shows that other breeds as well as mixed breeds have the mutation. These dogs also have difficulty breaking down other drugs as well as those used in anesthesia.
The mutation was also found in dogs related to Greyhounds such as the Borzoi, Scottish Deerhound, Italian Greyhound, and the Whippet. It was also discovered in Golden Retrievers, Labrador Retrievers and a few other breeds. These dogs have difficulty breaking down commonly used anesthetics midazolam, ketamine and propofol.
Fortunately, the scientists and veterinarians at Washington State University’s College of Veterinary Medicine are developing a cheek swab to identify dogs who have the genetic mutation.