The canine transmissible venereal tumor is spread in dogs worldwide through breeding as well as biting and licking the infected area. Professor Ariberto Fassati of UCL (University College London) has discovered that the disease is related to a single common ancestor, making it the same in all dogs. Professor Fassati also discovered that the dog’s immune system can cause the cancer to regress spontaneously or within a few weeks after only one radiotherapy or chemotherapy treatment.
Professor Fassati found that the healthy cells around the tumor were vital in causing the regression of the cancer. What is very exciting about this finding is that canine transmissible venereal tumor is very similar to various human cancers such skin cancer, bone cancer, and certain blood cancers. His research may lead the way to better treatments for humans.
“There are two key messages of our study,” Fassati says. “First, we should not focus on the cancer cells only but also understand the importance of normal tissue around the cancer in promoting rejection. Second, we must be able to induce the production of large amounts of certain chemokines to attract loads of immune cells to the tumor site.” His research may lead the way to better treatments for humans.