Dr. Catrin Rutland, Assistant Professor of Anatomy and Developmental Genetics at Nottingham’s School of Veterinary Medicine and Science, led a study with the Kazan Federal University and the Moscow State Academy of Veterinary Medicine and Biotechnology that discovered the use of DNA injections to cure injury related lameness in horses.
Within two months the horses were 100% restored to their pre-injury state. The gene therapy uses a combination of the Vascular Endothelial Growth Factor gene VEGF164, to enhance the growth of blood vessels and bone morphogenetic protein 2 (BMP2), which plays an important role in the development of bone and cartilage.
The genes were taken from horses and cloned into a DNA, which was not rejected by the horses that were treated since it was horse DNA. The current therapies for lameness at best has only a 40 to 80% success rate and can take up to 6 months for the horse to recover.
The DNA treatment resulted in the tissues in the horse’s limbs to be fully recovered. As a follow-up the horses were examined a year later and found to be 100% fit, active and pain free.
Not only is this good for horses, but the researchers hope that with further research, the method can be used on all animals, including people who suffer from similar injuries.